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Nejrychlejší čas v závěrečném tréninku na Velkou cenou Brazílie zajel dvojnásobný šampion Sebastian Vettel, druhé místo obsadil Jenson Button a třetí dokončil Mark Webber.
| P | # | Jezdec | Konstruktér | Čas | K | |
|---|---|---|---|---|---|---|
| 1 | 1 | Sebastian Vettel | Red Bull | 1:12.460 | 21 | |
| 2 | 4 | Jenson Button | McLaren | 1:12.547 | 19 | |
| 3 | 2 | Mark Webber | Red Bull | 1:12.597 | 21 | |
| 4 | 3 | Lewis Hamilton | McLaren | 1:12.622 | 15 | |
| 5 | 5 | Fernando Alonso | Ferrari | 1:12.765 | 17 | |
| 6 | 14 | Adrian Sutil | Force India | 1:13.113 | 22 | |
| 7 | 8 | Nico Rosberg | Mercedes | 1:13.286 | 21 | |
| 8 | 7 | Michael Schumacher | Mercedes | 1:13.393 | 19 | |
| 9 | 15 | Paul di Resta | Force India | 1:13.419 | 19 | |
| 10 | 6 | Felipe Massa | Ferrari | 1:13.583 | 18 | |
| 11 | 10 | Vitaly Petrov | Renault | 1:13.838 | 20 | |
| 12 | 11 | Rubens Barrichello | Williams | 1:14.283 | 19 | |
| 13 | 19 | Jaime Alguersuari | Toro Rosso | 1:14.286 | 20 | |
| 14 | 16 | Kamui Kobayashi | Sauber | 1:14.311 | 24 | |
| 15 | 12 | Pastor Maldonado | Williams | 1:14.454 | 22 | |
| 16 | 17 | Sergio Pérez | Sauber | 1:14.547 | 24 | |
| 17 | 9 | Bruno Senna | Renault | 1:14.551 | 15 | |
| 18 | 21 | Jarno Trulli | Lotus | 1:15.843 | 24 | |
| 19 | 20 | Heikki Kovalainen | Lotus | 1:16.026 | 22 | |
| 20 | 25 | Jérôme D’Ambrosio | Virgin | 1:16.616 | 26 | |
| 21 | 23 | Vitantonio Liuzzi | HRT | 1:17.143 | 23 | |
| 22 | 22 | Daniel Ricciardo | HRT | 1:17.296 | 23 | |
| 23 | 24 | Timo Glock | Virgin | 1:17.984 | 23 | |
| 24 | 18 | Sébastien Buemi | Toro Rosso | 3 |
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